Word spread quickly about the up-and-coming band, resulting in a recording contract with EMI. But before the Chili Peppers could begin work on their debut, Flea and Kiedis were dealt a disappointing blow when both Slovak and Irons announced that they were leaving to focus more on another band they were in, What Is This. With replacement members Jack Sherman (guitar) and Cliff Martinez (drums) filling in, the Peppers released their self-titled debut in 1984. But the absence of the two original members showed, as the album failed to capture the excitement of their live show. While the album didn't set the world on fire sales-wise, the group began to build a dedicated underground following with college radio buffs. By 1985, What Is This was kaput (after issuing a single self-titled album), as Slovak and Irons returned back to the Peppers, resulting in the George Clinton-produced Freaky Styley. While the album was an improvement over its predecessor, it still lacked the fire of the band's in-concert experience, a problem that would finally be solved with their next album, 1987's The Uplift Mofo Party Plan. The album was the group's first to make an impression on the charts, and they followed it up a year later with stopgap five-track release, The Abbey Road EP, in 1988. But just as the world was warming up to the Peppers, tragedy struck when Slovak died from a heroin overdose on June 25, 1988.

In the wake of Slovak's death, Irons left the group for the second and final time, while Kiedis (who was also battling drug addiction at the time) and Flea decided to soldier on. After a new lineup consisting of former Parliament guitarist Blackbyrd McKnight and former Dead Kennedys drummer D.H. Peligro didn't work out, the duo found worthy replacements in newcomers John Frusciante and Chad Smith. The new-look Chili Peppers hit pay dirt straight away, as their first album together, 1989's Mother's Milk, became a surprise hit due to MTV's exposure of their videos for a cover of Stevie Wonder's "Higher Ground" and a song about their fallen friend Slovak, "Knock Me Down," as the album was certified gold by early 1990. The group knew that their next release would be the most important one of their career, so they moved into a mansion-turned-recording studio with producer Rick Rubin to work on what would become their most successful release yet, the stripped-down Blood Sugar Sex Magik (their first for the Warner Bros. label). The album became a monster hit upon its September 1991 release (going on to eventually sell a staggering seven million copies in the U.S. alone), as it spawned such hits as "Give It Away" and the group's first Top Ten single, "Under the Bridge."

But not all was well in the Chili Peppers camp. Like his predecessor, Frusciante had become addicted to hard drugs, and abruptly left the band mid-tour in early 1992. Undeterred, the band enlisted new member Arik Marshall, and headlined Lollapalooza II in the summer. When the band returned to the studio to work on their sixth release overall, it quickly became apparent that Marshall didn't fit in, and was replaced by Jesse Tobias. But before Tobias could record a note with the group, he was handed his walking papers as well, and former Jane's Addiction guitarist Dave Navarro signed on. After a layoff of four years, the Peppers' much-delayed follow-up to BSSM was released in 1995, One Hot Minute. While the album was a sizeable hit, it failed to match the success and musical focus of its predecessor, as it became apparent during the album's ensuing tour that Navarro wasn't fitting in as well as originally hoped, and left the band in early 1998.

After Frusciante had left the group, he released a pair of obscure solo releases, 1995's Niandra Lades and Usually Just a T-Shirt and 1997's Smile from the Streets You Hold, yet rumors circulated that the guitarist was homeless, penniless, and sickly with a death-defying drug habit. After checking himself into rehab and putting his demons behind him, Frusciante emerged once again refocused and re-energized, and promptly accepted an invitation to rejoin the Peppers once more. The group's reunion album, 1999's Californication, proved to be another monster success, reconfirming the Chili Peppers as one of alternative rock's top bands. The band put in a quick guest appearance on Fishbone's Psychotic Friends Nuttwerx before hitting the road to support the album. The following months found the band getting involved in bizarre situations and controversies. First, their refusal to play songs from One Hot Minute during the tour was an unpopular decision with some fans and a sore spot for Dave Navarro. Next, they reignited a personal feud between Kiedis and Mr. Bungle singer Mike Patton by refusing to play a series of European concerts with Bungle. Patton responded with a "tribute" show for the Peppers, where Bungle mocked their stage moves, faked shooting up heroin, and imitated Kiedis' comments about Patton. They also played the ill-fated Woodstock '99 festival, where their headlining performance was met with piles of burning rubble and a full-scale riot. Tours with the Foo Fighters and Pearl Jam brought them into the next year without problems, but they stepped off the road after a planned stop in Israel was halted due to security worries. They returned to the studio in November of 2001 and by the summer of 2002 they had a new album ready to drop, By the Way. Warner Brothers released a Greatest Hits compilation in 2003, followed by a chart-topping two-CD album of all-new material, Stadium Arcadium, in 2006.